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Tcr repertoire3/17/2023 ![]() Thus, analysis of TCR CDR3 sequences has provided a useful means to study clonal expansions, repertoire breadth, and other properties such as CDR3 length polymorphisms, V(D)J gene usage, and sequence specificity of the T cell response. Because allelic exclusion leads to the expression of only one TCR chain in mature T cells, each unique CDR3 sequence is a proxy for T cell clonotype. This junctional region of the TCR chains, also known as the complementarity-determining region 3 (CDR3), is highly diverse and is an important determinant of antigen recognition by T cells. TCRβ chains are assembled by combinatorial somatic recombination events that splice together the variable (V), diversity (D), and joining (J) gene segments (VDJ). Ninety-five percent of T cells in the blood express T cell receptor (TCR) consisting of heterodimers of αβ chains. Taken together, these studies suggest a crucial role for T cells in the pathogenesis of SLE. Furthermore, murine SLE models show T cell expansions, the dependence of pathogenic anti-DNA autoantibodies production on CD4+ T cells, and slowed disease progression as a result of T cell depletion. In vitro studies show that T cells from SLE patients can recognize and proliferate in response to specific autoantigens such as nucleosomal histones and U1 small nuclear ribonucleoprotein A. ![]() Clonal expansion of T cells have been observed in SLE patients’ peripheral blood (PB) and various organs such as skin, kidney and gastrointestinal tract where they may be reactive to local antigens and drive tissue inflammation and injury. T cells play an essential role in SLE pathogenesis. Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder with complex etiology, diversity of clinical manifestations, and an unpredictable disease course. ![]()
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